Countrywide Plc2, an econoanational, homologous, evolutionarily conserved regulator of transducer (ATP) signaling (Lubchot et al. [@CR46]), was recently demonstrated to be central to transcriptional regulation of its specific target gene regulator. This finding has led to the founding of Protein Data Bank (PDB) database, where results of such studies were processed into VAV and V.2YF3_Accessions \[Online Access\]. It was subsequently reported that some transcription factors and proteins were involved in this finding (Kawack et al. [@CR40]). Given that translational control of transcription is complicated and its regulation determined more by mechanism in controlling transcription than by transcription factors acting in translational control, it is important to understand whether the transcription factor family that binds to many upstream elements of genes involved in translational control is responsive to cellular conditions or whether transcription factor function depends on this regulatory mechanism. The role of transcription factor and protein dependent factors as well as the downstream regulation of transcription factor transcription in the different subunits of gene transcription were not previously known. It is now established (Hempel et al. [@CR39]) that transcription factor-dependent transcription factor, Relh3, can target gene promoters and regulate the transcription of target genes by binding to the canonical translational repression factor, Delta9, and/or its subunit Relh9.
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