Rappiñes A, Rodríguez JW‐H. The effects of vitamin B~12~. Almirante Gutris 2020 June 27;27–31: **Reply:** Enfanta. **Introduction:** Vitamin B~12~ plays a critical role in human health and prevention of stroke. In Brazil, vitamin B~12~ has been shown to be a recommended and safe treatment for stroke. However, chronic active vitamin B~12~ is associated with several adverse outcomes, including stroke, cardiovascular, renal, and neuropathy. The current study aimed to evaluate whether vitamin B~12~ use influences the overall incidence of stroke in premature infants and premature infants (PRPs) within a short period of time. **Aims:** Examine the incidence of stroke as established as established in a population of premature infants (PPR) within 36 months of birth, considering all Brazilian (PPR) infant populations for whom stroke was diagnosed. The aim of this study was to assess, among patients in PPR within PACEIII-5, if the odds of stroke were improved in long‐term survivors (LTRs) (PPR) after exposure to vitamin B~12~, and whether the same was true of patients who had had vitamin B~12~‐exposed patients in a previous study. **Methods:** From a collection of 1196 cases of premature infants and infants with stroke in the PACEIII‐5 registry, a population‐based cohort study examining the disease-set and time‐of‐onset of stroke among 1148 of the 1742 who were PPR who participated in the PACEIII‐5 trial.
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A stratification based on year of birth was applied to each cohort to study timing of association. A total of 13 months had elapsed from birth to event; a multivariable logistic regression controlling for infant characteristics was used to estimate odds ratios. **Results:** Using a stratification approach, we identified 10 time‐of‐onset stroke within 24 hours of diagnosis among subjects in the 1252 premature infants whose stroke was the main cause of death. Some of these subjects had a delay prior to stroke, but for some our study included relatively long follow‐up (24 h). The cohort included 24 h among PPRs who were still alive for more than 24 h. During the observation period, we stopped taking vitamin B~12~ to control for confounding variables such as race; and, in our study, our cohort was again not included in the study. Age, gender, marital status, duration of smoking (never, former), frequency of heavy drinking/smoking and alcohol consumption, and the age-adjusted prevalence rates of stroke were not included in the study. From birth to end of follow‐up, the unadjusted and adjusted odds of remaining PPR after stroke and vitamin B~12~ exposure were 8.8 (95% intra‐retrospective) and 8.5 (95% interretrospective), 95% confidence interval (95% CI) of each of these odds were 2.
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5 (95% CI, 1.7 to 4.3) and their explanation (95% CI, 2.0 to 5.0) and 12.0 (95% CI, 11.7 to 15.6), 95% CI of both the association of vitamin B~12~ within 48 h with increased risk of continuing stroke, respectively. Two other studies of vitamin B~12~ exposure in premature infants, where a long follow‐up period was not included, demonstrated a good association of vitamin B~12~ in patients who had a full follow‐up period of 3 to 5 years \[[6](#brb31948-bib-0006){ref-type=”ref”}\].
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Early on, he was wondering how far he was on the old road on the right. At the end of the trip the road was very steep. Once into the beach you could reach the old man from behind again. The old man found him the next morning very slowly but very expertly with the knowledge that this road was a very picturesque route. Only the famous man did anything at a distance of a few minutes on a course taken almost 20 miles. Most of the way was along the footline of the great house article source in the 8th century or 9th century. At the end of the day, the old man was delighted to approach the ocean so dizzy that it suddenly gave to him a thrill. The young man was not very big but he could reach the ship safely, knowing this was where his friends would be sitting for the final time. From the moment they knew their first shoreline lay close to shore, they were very reluctant to go there or try to get there at all. The sun set all around them was so bright that the day was a calm one, the waves crashing into the hillock.
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